Holy Basil known to the scientific world as Ocimum sanctum is indigenous plant to India. Hindus regard it as an earthly manifestation of goddess Vrindavani, who is dear to Lord Vishnu. It is traditionally used in number of disease condition and has also been extensively studied for its pharmacological properties, which mainly include anticancer, antistress, wound healing, immunostimulant, antioxidant, radioprotection, antithyroidic, anti-inflammatory and antiHIV etc.

The Ocimum sanctum was found to possess significant antiulcer activity against aspirin-, indomethacin-, alcohol-, histamine-, reserpine-, serotonin- and stress-induced ulceration in experimental animal models. Significant inhibition was also observed in gastric secretion and aspirin-induced gastric ulceration in pylorus ligated rats. Yet another preclinical studies confirmed the antiulcerogenic property of Ocimum sanctum. The Ocimum sanctum extract reduced the ulcer index, free & total acidity on acute and chronic administration. Seven days pretreatment with the Ocimum sanctum increased the mucous secretion also. It was concluded that Ocimum sanctum extract has antiulcerogenic property against experimental ulcers, and it was due to its ability to reduce acid secretion and increase mucous secretion.

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