Box myrtle scientifically known as Myrica nagi is a sub-temperate evergreen tree found throughout the mid-Himalayas. The tree yields a drupaceous fruit, which is one of the tastiest wild fruits of the sub-Himalayan region. This fruit carries a lot of commercial importance. The bark of Myrica nagi is said to possess many medicinal properties like antiarthritic, antiseptic, aromatic, astringent, carminative, ophthalmic and stimulant. It has proved useful in the treatment of fevers, asthma and coughs.

Many studies have proved the protective effect of Myrica nagi. Application of Myrica nagi at doses of 2.0 mg and 4.0 mg/kg body weight in acetone prior to that of cumene hydroperoxide (30 mg/animal/0.2 ml acetone) treatment resulted in significant inhibition of cumene hydroperoxide-induced cutaneous oxidative stress and toxicity in a dose-dependent manner. Enhanced susceptibility of cutaneous microsomal membrane for lipid peroxidation induced by iron ascorbate and xanthine oxidase activities were significantly reduced (P<0.05). In addition the depleted level of glutathione, the inhibited activities of antioxidants, and phase II metabolizing enzymes were recovered to a significant level (P<0.05). The protective effect of Myrica nagi was dose-dependent. The study suggests that Myrica nagi is an effective chemopreventive agent in skin and capable of ameliorating cumene hydroperoxide-induced cutaneous oxidative stress and toxicity.

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