|
 |
 |
| |
| RESEARCH
STATUS
|
| Clinical
data |
Pending |
| Preclinical
data |
Available |
| Short
term Toxicity data |
Available |
| Long
term Toxicity date |
Pending |
| Phytochemical
standardization |
Pending |
|
Many a times Allergens present in the environment tigger various
allergic reactions. One of the most fatal is Asthma. Nearly four
out of ten childern suffer from asthma and the risk factor related
to this diseases is increases day by day. Allergens causes the lining
of the airways to become swollen and inflamed. It produces extra
mucus and the muscle of the airways tighten due to which there is
less room left for the air to pass in and out which leads to breathlessness.
The growing environmental pollution with rapid and extensive industrialization
is also responsible for aggravation of this disease. The alarming
rise in the incidence of this disease in metropolitan cities has
posed a serious problem.
Lybergic is derived from the bark of large deciduous tree commonly
occurring in the Himalayas. Lybergic showed significant protection
against histamine induced respiratory challenge in Guinea pigs.
Dosage / Suggested Use: 1 capsule tid
PHARMACOLOGICAL EFFECTS OF LYBERGIC
| Model |
Dose |
Results |
| Antiasthama
activity against histamine induced bronchspasm in guinea
pigs. |
Lybergic
(100 mg/kg b.w & 200 mg/kg b.w) Chlorpheneramine maleate
(4.5 mg/kg po) |
Lybergic
was able to give protection from histamine challenge to
the extent of 75% and 87.5% at 100 mg/kg and 200 mg/kg
doses. |
| Passive
paw anaphylaxis model in rats. |
Lybergic
(100 mg/kg b.w and 200 mg/kg b.w)
Dexamethasone as a reference standard
(1 mg/kg of body weight)
|
Lybergic
at the dose of 100 and 200 mg/kg demonstrated significant
(P<0.05) decrease in the rat paw edema to the extent
of 33.09% and 42.48 % respectively. |
|
|
|
SAFETY
Acute Oral Toxicity study
The LD50 established at > 2 gm/kg
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, cure,
treat or prevent any disease. |
| |
|
|
|
|
