| RESEARCH
STATUS
|
| Clinical
data |
Pending |
| Preclinical
data |
Available |
| Short
term Toxicity data |
Available |
| Long
term Toxicity date |
Pending |
| Phytochemical
standardization |
Pending |
|
Inflammatory conditions occur in several common disorders including
rheumatoid arthritis, osteoarthritis, lumbago, etc… Selective
COX2 inhibitory activity has come under a cloud due the recent controversy
regarding Bextra, Celebrex and Vioxx. Natural agents containing
more than one anti-inflammatory compounds are expected to act by
multiple mechanisms. The commonest adverse effects of COX inhibitors
(particularly COX1 inhibitors like Aspirin) are gastric irritation
effects and if overused, gastric ulcerations. Due to multiple mechanisms
of the multiple phyto-compounds, lower doses may be acting synergistically
in herbs. Hence the value of newer anti-inflammatory herbs that
have been proven safe and active.
Lanconone is balanced combination of extracts which has scientifically
demonstrated significant Antiinflammatory activity.
Dosage / Suggested Use: As a dietary supplement take 1 capsules
3 times a day.
PHARMACOLOGICAL EFFECTS OF ENTOX
| Model |
Dose |
Results |
| Antiinflammatory
activity by Carageenan induced hind paw oedema in rats.
|
Lanconone
400 mg/kg body wt
Standard drug Diclofenac 10mg/kg
|
Lanconone
reduced the inflammation to the extent of 72.83% and 75%
at 4th and 6th hour, respectively which is significantly
comparable to the standard drug. |
|
CLINICAL
STUDY OUTLINE
Design: A Double Blind, Randomized,
Parallel group, Multicentric study.
Objective: To investigate the safety,
tolerability and efficacy of LANCONONE- " A Dietary
Supplement" in providing relief from symptoms of pain,
stiffness and immobility to patients with moderate conditions
of Osteoarthritis of the knee.
Duration of Treatment: 12 weeks
Number of subjects: 30
SAFETY
Acute Oral Toxicity study
The LD50 established at > 2 gm/kg
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, cure,
treat or prevent any disease. |
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