| RESEARCH
STATUS
|
| Clinical
data |
Pending |
| Preclinical
data |
Available |
| Short
term Toxicity data |
Available |
| Long
term Toxicity date |
Pending |
| Phytochemical
standardization |
Pending |
|
As Effective as NSAIDs & significantly more tolerable
Inflammatory conditions occur in several common disorders including
rheumatoid arthritis, osteoarthritis, lumbago, etc… Selective
COX2 inhibitory activity has come under a cloud due the recent controversy
regarding Bextra, Celebrex and Vioxx. Natural agents containing
more than one anti-inflammatory compounds are expected to act by
multiple mechanisms. The commonest adverse effects of COX inhibitors
(particularly COX1 inhibitors like Aspirin) are gastric irritation
effects and if overused, gastric ulcerations. Due to multiple mechanisms
of the multiple phyto-compounds, lower doses may be acting synergistically
in herbs. Hence the value of newer anti-inflammatory herbs that
have been proven safe and active.
Lanciflam is a research product from Exotic Naturals. Lanciflam
is the extract derived from medicinal plant mainly growing in North
India. Lanciflam demonstrated significant anti-inflammatory activity
at the dose of 200mg/kg body weight against carrageen induced paw
oedema in albino rats. In addition, Lanciflam did not induced ulcers
at therapeutic doses.
Dosage / Suggested Use
As a dietary supplement take 1 capsules 3 times a day.
PHARMACOLOGICAL EFFECTS OF LANCIFLAM
| Model |
Dose |
Results |
| Antiinflammatory
activity in Carageenan induced hind paw oedema in albino
rats |
Lanciflam
200 mg/kg bw |
Lanciflam
200mg/kg produced anti-inflammatory activity statistically
equivalent to that of Diclofenac Sod. 4.5 mg/kg without
causing gastritis. |
| 1,
1-diphyenyl-picryl hydrazyl (DPPH) Antioxidant assay |
|
The
anti oxidant activity of Lanciflam is comparable with
that of standard, Curcumin used in the study |
| Antiinflammatory
activity in Carageenan induced hind paw oedema in albino
rats |
Lanciflam
(fraction obtained by successive fractionation) 100 mg/kg
b.w & Ibuprofen (40 mg/kg b.w) used as standard |
Lanciflam
showed 76.87% and 86.60 % reduction in paw edema at 2hr
and 4th hr which is significant when compared to standard
drug Ibuprofen 92.68% and 73.30% at 2nd and 4th hr. Lanciflam
has long term effect as it is showing maximum reduction
at 4th hr which is better than Ibuprofen. |
|
CLINICAL STUDY OUTLINE
Design: A Double Blind, Randomized,
Parallel Group Multi centric GCP compliant Study.
Objective: To evaluate the Efficacy,
Safety, Tolerability of Lanciflam - " A Dietary Supplement"
in providing relief from symptoms of pain, stiffness and immobility
to patients with moderate conditions of Osteoarthritis of the
knee.
Treatment Duration: 12 weeks
Number of Subjects: 30
SAFETY
Acute Oral Toxicity study
The LD50 established at > 2 gm/kg
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, cure,
treat or prevent any disease. |
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