| RESEARCH
STATUS
|
| Clinical
data |
Pending |
| Preclinical
data |
Available |
| Short
term Toxicity data |
Available |
| Long
term Toxicity date |
Pending |
| Phytochemical
standardization |
Pending |
|
Delivers restful sleep
Promotes natural body biorhythms
Non-habit forming & Diphenhydramine-free
Sleeplessness is a very common problem affecting a large percentage
of people today across the world. Sleep problems are, however, surprisingly
common among young people. Stress is the cause of 80% of all diseases.
About 60 million Americans each year suffer from sleeplessness,
which leads to serious sleep deficits and other problems. It affects
about 40 percent of women and 30 percent of men.
The use of these modern drugs for long time leads to addiction.
In recent years with the advancement and scientific approach in
the field of ayurveda, there is an increasing interest in the use
of herbs/plants various therapeutic indications.
DREEMZON is a unique polyherbal formulation containing an array
of effective and standardized extracts of traditionally known scientifically
proven herbs to counteract stress levels and calm mind naturally
without the side effects normally associated with sleeping piles.
Preclinical studies of Dreemzon have significant CNS depressant
effect with concomitant mild analgesic activity. Hence Dreemzon
is helpful in stressful conditions, anxiety, loss of sleep and excitation
of CNS.
Dosage / Suggested Use: As a dietary supplement take 2 capsules
2 hours before bedtime only.
PHARMACOLOGICAL EFFECTS OF DREEMZON
| Model |
Observation |
| NEUROPHARMACOLOGICAL
ACTIVITY OF DREEMZON IN SWISS ALBINO MICE |
Behavioral
studies
- Spontaneous
Activity, Awareness, & Alertness
- Passivity,
Stereotypy and Visual Placing
- Mood
- Touch
and pain responses
|
- The
reduction in the spontaneous activity gives an indication
of decreased level of the excitability of the CNS.
-
Locomotion and rearing was suppressed.
-
There was dose dependant decrease in level of awareness
and alertness in animals.
-
There was no vocalization and stereotypy seen.
-
After two hours of oral dosing the animals went into
sleep for 1.5-2.0 hours.
-
Touch and pain responses were also diminished at doses
500mg/kg and above.
|
Neurological
profile
-
Central Excitation
-
Motor-In co-ordination
-
Reflexes
|
-
There was no CNS excitation observed at any dose.
- There
was no significant increase in the body weight and
no major changes in the quality of fur.
|
| Study
of Gait |
There
was no significant increase in the variability of the
width of the gait, which indicates that Dreemzon was unable
to produce ataxia. |
| Rotarod
test |
From
the results of the Rota rod test, it can also be concluded
that the formulation unable to produce motor in co-ordination. |
| Narcosis
Potentiation test |
There
was dose dependant increase in the sleep time in the animals |
|
SAFETY
Acute Oral Toxicity study
The LD50 established at > 2 gm/kg
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, cure,
treat or prevent any disease. |
| |
|
|
|
